Colossae was an ancient city of southern Phrygia, the extensive western part of Anatolia, overhanging the Lykos (a tributary of the Meander) on the upper part of its course. The city was some ten miles from Laodikeia and thirteen from Hierapolis [Col. 2:1, 4:13, 15,16; Rev. 1: 11]. The three cities formed a single sphere of missionary labor for Epaphras, an inhabitant of Colossae [Col. 1:7, 4:12, 13]. The city originally lay on the Colossae Mapmain trade route from Ephesus to the Euphrates and the East, at the junction of the highways to Sardis and Pergamon.